I A Hughes Selected Research

Androgen-Insensitivity Syndrome (Testicular Feminization)

11/2016	The Long-Term Outcome of Boys With Partial Androgen Insensitivity Syndrome and a Mutation in the Androgen Receptor Gene.
11/2016	Identification of an AR Mutation-Negative Class of Androgen Insensitivity by Determining Endogenous AR Activity.
1/2013	Variable loss of functional activities of androgen receptor mutants in patients with androgen insensitivity syndrome.
1/2012	A cell model for conditional profiling of androgen-receptor-interacting proteins.
10/2008	A novel mutation in the human androgen receptor suggests a regulatory role for the hinge region in amino-terminal and carboxy-terminal interactions.
4/2006	Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains.
3/2006	Testicular development in the complete androgen insensitivity syndrome.
7/2005	Correlation between genotype, phenotype and sex of rearing in 111 patients with partial androgen insensitivity syndrome.
2/2000	Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome.

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I A Hughes Research Topics

Disease

9	Androgen-Insensitivity Syndrome (Testicular Feminization) 11/2016 - 02/2000
3	Cryptorchidism (Undescended Testes) 01/2020 - 11/2009
3	Hypospadias 11/2016 - 09/2002
2	Weight Gain 01/2021 - 08/2002
2	Neoplasms (Cancer) 10/2017 - 03/2006
2	Insulin Resistance 02/2010 - 06/2003
2	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 08/2003 - 05/2003
2	Body Weight (Weight, Body) 06/2003 - 08/2002
1	Obesity 01/2021
1	Gestational Diabetes (Gestational Diabetes Mellitus) 09/2017
1	46,XY Disorder of Sex Development (Male Pseudohermaphroditism) 12/2012
1	Precocious Puberty 12/2008
1	Penis agenesis 07/2005
1	Congenital Abnormalities (Deformity) 08/2003
1	Birth Weight (Birth Weights) 09/2002
1	Virilism (Virilization) 08/2002
1	WAGR Syndrome (Syndrome, WAGR) 12/2001
1	Persistent Mullerian duct syndrome 09/2001
1	46,XY Gonadal Dysgenesis (Swyer Syndrome) 12/2000
1	Denys-Drash Syndrome 01/2000

Drug/Important Bio-Agent (IBA)

7	Androgen Receptors (Androgen Receptor)IBA 11/2016 - 02/2000
7	AndrogensIBA 12/2012 - 12/2001
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2003
2	Testosterone (Sustanon)FDA Link 11/2016 - 01/2000
2	Hormones (Hormone)IBA 12/2008 - 09/2001
2	Dexamethasone (Maxidex)FDA LinkGeneric 08/2003 - 08/2002
1	LipidsIBA 01/2021
1	stearoyl-coenzyme A (stearoyl-CoA)IBA 01/2021
1	Fatty Acid DesaturasesIBA 01/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	Cholesterol Esters (Cholesteryl Esters)IBA 01/2021
1	bisphenol AIBA 01/2020
1	Phenol (Carbolic Acid)FDA Link 01/2020
1	ParabensIBA 01/2020
1	phthalic acid (phthalate)IBA 01/2020
1	Dihydrotachysterol (AT 10)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 09/2017
1	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2016
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 12/2008
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 12/2008
1	LigandsIBA 04/2006
1	GlucocorticoidsIBA 06/2003
1	SteroidsIBA 06/2003
1	LeptinIBA 06/2003
1	prednylidene (Pred)IBA 08/2002
1	Phosphotransferases (Kinase)IBA 09/2001
1	NucleotidesIBA 12/2000
1	Oxidoreductases (Dehydrogenase)IBA 01/2000

Therapy/Procedure

1	Castration 10/2017
1	Operative Surgical Procedures 11/2016